Ethionamide

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Ethionamide
File:Ethionamide.png
Systematic (IUPAC) name
2-ethylpyridine-4-carbothioamide
Pharmacokinetic data
Protein binding Approximately 30% bound to proteins.
Biological half-life 2 to 3 hours
Identifiers
CAS Number 536-33-4
ATC code J04AD03 (WHO)
PubChem CID 2761171
DrugBank APRD00961
Chemical data
Formula C8H10N2S
Molar mass 166.244 g/mol[[Script error: No such module "String".]]
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Ethionamide (2-ethylthioisonicotinamide, Trecator SC) is an antibiotic used in the treatment of tuberculosis.

It is a prodrug.[1]

It has been proposed for use in combination with gatifloxacin.[2]

The action may be through disruption of mycolic acid.[3]

Synthesis

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Liberman, D.; Rist, N.; Grumbach, F.; Cals, S.; Moyeux, M.; Rouaix, A.; Bull. Soc. Chim. Fr. 1958, 687.

References

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