Fenbendazole

Fenbendazole

File:Fenbendazole.svg
Systematic (IUPAC) name
methyl N-(6-phenylsulfanyl-1H-benzoimidazol- 2-yl)carbamate
Identifiers
CAS Number	43210-67-9
ATC code	P02CA06 (WHO) QP52AC13
PubChem	CID 3334
Chemical data
Formula	C15H13N3O2S
Molar mass	299.349 g/mol[[]]

Fenbendazole (Hoechst brand names Panacur and Safe-Guard, Intervet Panacur and Panacur Rabbit) is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including roundworms, hookworms, whipworms, the taenia species of tapeworms, pinworms, aelurostrongylus, paragonimiasis, strongyles and strongyloides and can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits and seals. Drug interactions may occur if using bromsalan flukicides such as dibromsalan and tribromsalan. Abortions in cattle and death in sheep have been reported after using these medications together.

Toxicity

Despite being widely used as a dewormer in many species, toxicity has been reported. Birds (storks, pink pelicans, vultures, pigeons and doves), and reptiles (vipers, turtles and tortoises) have shown toxicity associated with bone marrow suppresion, intestinal crypt cell necrosis and distal villi sloughing. Abortions in domestic ruminants have been associated with concurrent use of anti-trematode therapeutic agents.

Fenbendazole is poorly absorbed from the gastrointestinal tract in most species. The LD₅₀ in laboratory animals exceeds 10 g/kg when administered orally.

External links

• PetPlace Drug Library
• 3Dchem.com – Chemical structure