GR-127,935

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GR-127,935
File:GR-127,935 structure.png
Systematic (IUPAC) name
N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1-1'-biphenyl-4-carboxamide
Identifiers
CAS Number 148672-13-3
ATC code none
PubChem CID 107780
IUPHAR/BPS 14
Chemical data
Formula C29H31N5O3
Molar mass 497.587 g/mol[[Script error: No such module "String".]]
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GR-127,935 is a drug which acts as a selective antagonist at the serotonin receptors 5-HT1B and 5-HT1D.[1] It has little effect when given by itself but blocks the antiaggressive effect of 5-HT1B agonists,[2] and alters release of serotonin in the brain,[3] as well as reducing drug-seeking behaviour in cocaine addicted rats.[4]

See also

References

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  1. Skingle M, Beattie DT, Scopes DI, Starkey SJ, Connor HE, Feniuk W, Tyers MB (1996). "GR127935: a potent and selective 5-HT1D receptor antagonist". Behavioural Brain Research. 73 (1-2): 157–61. doi:10.1016/0166-4328(96)00089-7. PMID 8788495. 
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  4. Przegaliński E, Gołda A, Filip M (2008). "Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats". Pharmacological Reports : PR. 60 (6): 798–810. PMID 19211971.