Gemfibrozil

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Gemfibrozil
File:Gemfibrozil.svg
Systematic (IUPAC) name
5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acid
Clinical data
Pregnancy
category
  • Category C
Routes of
administration
Oral
Legal status
Legal status
  • By Prescription
Pharmacokinetic data
Bioavailability Close to 100%
Protein binding 95%
Metabolism Hepatic (CYP3A4)
Biological half-life 1.5 hours
Excretion Renal 94%
Feces 6%
Identifiers
CAS Number 25812-30-0
ATC code C10AB04 (WHO)
PubChem CID 3463
DrugBank APRD00293
ChemSpider 3345
Chemical data
Formula C15H22O3
Molar mass 250.333 g/mol[[Script error: No such module "String".]]
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Gemfibrozil is the generic name for an oral drug used to lower lipid levels. It belongs to a group of drugs known as fibrates. It is most commonly sold as the brand name, Lopid. Other brand names include Jezil and Gen-Fibro.

Actions

Therapeutic effects

Nontherapeutic effects and toxicities

Indications

Contraindications and Precautions

  • Gemfibrozil should not be given to these patients:
    • Hepatic dysfunction
    • Renal dysfunction
  • Gemfibrozil should be used with caution in these higher risk categories:
    • Biliary Tract Disease
    • Pregnant women
    • Obese patients
    • Native Americans

Drug Interactions

  • Anticoagulants: Gemfibrozil potentiates the action of coumadin and indanedione anticoagulants.
  • Statin drugs: Concomitant administration of fibrates (including gemfibrozil) with statin drugs increases the risk of muscle cramping, myopathy, and rhabdomyolysis.

External links

es:Gemfibrozil

it:Gemfibrozil nl:Gemfibrozil pl:Gemfibrozyl pt:Genfibrozila ru:Гемфиброзил