Halazepam
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| Systematic (IUPAC) name | |
|---|---|
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7-chloro- 5-phenyl- 1-(2,2,2-trifluoroethyl) -1,3-dihydro- 2H-1,4-benzodiazepin- 2-one | |
| Clinical data | |
| Pregnancy category |
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| Routes of administration | Oral |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | Hepatic |
| Biological half-life | ? |
| Excretion | Renal |
| Identifiers | |
| CAS Number | 23092-17-3 |
| ATC code | N05BA13 (WHO) |
| PubChem | CID 31640 |
| DrugBank | APRD01009 |
| Synonyms | 9-chloro- 6-phenyl- 2-(2,2,2-trifluoroethyl)- 2,5-diazabicyclo[5.4.0] undeca- 5,8,10,12-tetraen -3-one |
| Chemical data | |
| Formula | C17H12ClF3N2O |
| Molar mass | 352.7[[Script error: No such module "String".]] |
| (verify) | |
Halazepam is a benzodiazepine derivative and is marketed under the brand names Alapryl and Pacinone. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a trifluoroethyl derivative of nordazepam.[1] While its structure may be similar to chlordiazepoxide and diazepam, it has both less toxicity and less tendency to cause paradoxical hostility and aggression than either of them.[2] Halazepam has active benzodiazepine metabolites.[3]
Indications
Halazepam is indicated for the treatment of anxiety.[4]
See also
References
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- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Jochemsen R, Breimer DD (1984). "Pharmacokinetics of benzodiazepines: metabolic pathways and plasma level profiles". Curr Med Res Opin. 8 Suppl 4: 60–79. PMID 6144464.
- ↑ Lozano, Lozano, Lozano; et al. (1990). "[Open clinical study of the efficacy and safety of Halazepam in anxiety disorders]". Actas Luso Esp Neurol Psiquiatr Cienc Afines (in Spanish; Castilian). 18 (4): 205–11. PMID 1981637.
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