Hypocretin (orexin) receptor 1

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Hypocretin (orexin) receptor 1
Identifiers
SymbolsHCRTR1; OX1R
External IDsOMIM: 602392 MGI: 2385650 HomoloGene: 37492 IUPHAR: OX1 GeneCards: HCRTR1 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez3061230777
EnsemblENSG00000121764ENSMUSG00000028778
UniProtO43613Q0VDP5
RefSeq (mRNA)NM_001525XM_983697
RefSeq (protein)NP_001516XP_988791
Location (UCSC)Chr 1:
31.86 - 31.87 Mb		Chr 4:
129.63 - 129.64 Mb
PubMed search[1][2]

Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1, is a protein that in humans is encoded by the HCRTR1 gene.[1]

Function

The orexin 1 receptor (OX1), is a G-protein coupled receptor expressed in the hypothalamus and involved in the regulation of feeding behaviour. OX1 selectively binds the orexin-A neuropeptide. It shares 64% identity with OX2.[1]

Ligands

Agonists

Antagonists

See also

References

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External links

  • "Orexin Receptors: OX1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

  • Flier JS, Maratos-Flier E (1998). "Obesity and the hypothalamus: novel peptides for new pathways". Cell. 92 (4): 437–40. doi:10.1016/S0092-8674(00)80937-X. PMID 9491885. 
  • Willie JT, Chemelli RM, Sinton CM, Yanagisawa M (2001). "To eat or to sleep? Orexin in the regulation of feeding and wakefulness". Annu. Rev. Neurosci. 24: 429–58. doi:10.1146/annurev.neuro.24.1.429. PMID 11283317. 
  • Hungs M, Mignot E (2001). "Hypocretin/orexin, sleep and narcolepsy". Bioessays. 23 (5): 397–408. doi:10.1002/bies.1058. PMID 11340621. 
  • de Lecea L, Kilduff TS, Peyron C; et al. (1998). "The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 322–7. doi:10.1073/pnas.95.1.322. PMC 18213 Freely accessible. PMID 9419374. 
  • Sakurai T, Amemiya A, Ishii M; et al. (1998). "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior". Cell. 92 (4): 573–85. doi:10.1016/S0092-8674(00)80949-6. PMID 9491897. 
  • Sakurai T, Amemiya A, Ishii M; et al. (1998). "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior". Cell. 92 (5): 1 page following 696. doi:10.1016/S0092-8674(00)80949-6. PMID 9527442. 
  • Peyron C, Faraco J, Rogers W; et al. (2000). "A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains". Nat. Med. 6 (9): 991–7. doi:10.1038/79690. PMID 10973318. 
  • Blanco M, López M, GarcIa-Caballero T; et al. (2001). "Cellular localization of orexin receptors in human pituitary". J. Clin. Endocrinol. Metab. 86 (7): 1616–9. doi:10.1210/jc.86.4.1616. PMID 11443222. 
  • Olafsdóttir BR, Rye DB, Scammell TE; et al. (2002). "Polymorphisms in hypocretin/orexin pathway genes and narcolepsy". Neurology. 57 (10): 1896–9. PMID 11723285. 
  • Wieland HA, Söll RM, Doods HN; et al. (2002). "The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor". Eur. J. Biochem. 269 (4): 1128–35. doi:10.1046/j.0014-2956.2001.02739.x. PMID 11856342. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. 
  • Hilairet S, Bouaboula M, Carrière D; et al. (2003). "Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716". J. Biol. Chem. 278 (26): 23731–7. doi:10.1074/jbc.M212369200. PMID 12690115. 
  • Karteris E, Chen J, Randeva HS (2004). "Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system". J. Clin. Endocrinol. Metab. 89 (4): 1957–62. doi:10.1210/jc.2003-031778. PMID 15070969. 
  • Holmqvist T, Johansson L, Ostman M; et al. (2005). "OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms". J. Biol. Chem. 280 (8): 6570–9. doi:10.1074/jbc.M407397200. PMID 15611118. 
  • Spinazzi R, Rucinski M, Neri G; et al. (2005). "Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells". J. Clin. Endocrinol. Metab. 90 (6): 3544–9. doi:10.1210/jc.2004-2385. PMID 15797953. 
  • Meerabux J, Iwayama Y, Sakurai T; et al. (2005). "Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects". Biol. Psychiatry. 58 (5): 401–7. doi:10.1016/j.biopsych.2005.04.015. PMID 15978554. 
  • Ziolkowska A, Spinazzi R, Albertin G; et al. (2006). "Orexins stimulate glucocorticoid secretion from cultured rat and human adrenocortical cells, exclusively acting via the OX1 receptor". J. Steroid Biochem. Mol. Biol. 96 (5): 423–9. doi:10.1016/j.jsbmb.2005.05.003. PMID 16157481. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened
  1. ↑ 1.0 1.1 "Entrez Gene: HCRTR1 hypocretin (orexin) receptor 1". 
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