Insulin receptor substrate
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Revision as of 05:47, 3 May 2010 by Beam0902 (Talk) (Substituted "phosphotyrosine binding" for "PTB" and inserted link to phosphotyrosine page)
Insulin receptor substrate (IRS) is an important ligand in the insulin response of human cells.
IRS-1, for example, is an IRS protein which contains a phosphotyrosine binding-domain (PTB-domain). In addition, the insulin receptor contains a NPXpY domain. The PTB-domain binds the NPXpY domain. Thus, the insulin receptor binds IRS.
Genes
- IRS1 (see also Insulin receptor substrate 1)
- IRS2 (see also Insulin receptor substrate 2)
- IRS3L
- IRS4
References
- van der Geer P, Wiley S, Pawson T (1999). "Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site". Oncogene. 18 (20): 3071–5. doi:10.1038/sj.onc.1202879. PMID 10340378.
