Difference between revisions of "Myocardial depressant factor"

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Latest revision as of 21:28, 21 September 2010

Myocardial depressant factor (MDF) is a low-molecular-weight peptide[1] released from the pancreas into the blood in mammals during various shock states. [2]

MDF is a significant mediator of shock pathophysiology, reducing myocardial contractility, constricting splanchnic arteries and impairing phagocytosis by the reticuloendothelial system. Survival can be improved by preventing its release or blocking its activity, for example using glucocorticoids, prostaglandins, aprotinin, captopril, imidazole or lidocaine.

References

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  1. MeSH Myocardial+Depressant+Factor
  2. Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.