Naltriben
From Self-sufficiency
| File:Naltriben.png | |
| Identifiers | |
|---|---|
| CAS Number | 111555-58-9 |
| ATC code | none |
| PubChem | CID 5486827 |
| IUPHAR/BPS | 1640 |
| Chemical data | |
| Formula | C26H25NO4 |
| Molar mass | 415.480 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
Naltriben is a potent and selective antagonist for the delta opioid receptor, which is used in scientific research. It has similar effects to the more widely used δ antagonist naltrindole, but with different binding affinity for the δ1 and δ2 subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors.[1] It also acts as a κ-opioid agonist at high doses.[2]
References
- ↑ Sofuoglu M, Portoghese PS, Takemori AE. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. Journal of Pharmacology and Experimental Therapeutics. 1991 May;257(2):676-80. PMID 1851833
- ↑ Stewart PE, Holper EM, Hammond DL. Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes. Life Sciences. 1994;55(4):PL79-84. PMID 8028443
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- Opioids
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