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Systematic (IUPAC) name
Legal status
Legal status
  • Uncontrolled
PubChem CID 9794656
Chemical data
Formula C14H19NO2
Molar mass 233.305 g/mol[[Script error: No such module "String".]]
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ORG-37,684 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes.[1][2] It has anorectic effects in animal studies and has been researched as a potential weight loss drug for use in humans.[3]


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  1. Adams, D.; Duncton, M. (2001). "EFFICIENT SYNTHESIS OF THE 5-HT2C RECEPTOR AGONIST, ORG 37684". Synthetic Communications. 31: 2029. doi:10.1081/SCC-100104420.  edit
  2. Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M. Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Archives of Pharmacology. 2004;370:114-123. PMID 15322733
  3. Schreiber R, De Vry J. Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat. Progress in Neuropsychopharmacology and Biological Psychiatry. 2002 Apr;26(3):441-9. PMID 11999893