Opiorphin

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Opiorphin[1]
File:Opiorphin.png
style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers
CAS number 864084-88-8 YesY
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style="background: #F8EABA; text-align: center;" colspan="2" | Properties
Molecular formula C29H48N12O8
Molar mass 692.77 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Opiorphin is an endogenous chemical compound first isolated from human saliva. Initial research with mice shows the compound has a painkilling effect greater than that of morphine. It works by stopping the normal breakdown of natural pain-killing opioids in the spine, called enkephalins. It is a relatively simple molecule consisting of a five-amino acid polypeptide, Gln-Arg-Phe-Ser-Arg.[2][3][4][5][6][7][8][9]

Opiorphin pentapetide originates from the N-terminal region of the protein PROL1 (proline rich, lacrimal 1).[2] Opiorphin inhibits two proteases: neutral ecto-endopeptidase (MME) and ecto-aminopeptidase N (ANPEP).[2]

See also

References

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  1. Opiorphin at Sigma-Aldrich
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  3. Andy Coghlan (November 13, 2006). "Natural-born painkiller found in human saliva". New Scientist. 
  4. "Natural chemical 'beats morphine'". BBC News. November 14, 2006. 
  5. Mary Beckman (November 13, 2006). "Prolonging Painkillers". ScienceNOW. 
  6. Stanovic S, Boranic M, Petrovecki M, Batinic D, Skodlar J, Nemet D, Labar B. Haematologia. 2000; 30(1):1-10.
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