View source for P2RY6

{{PBB|geneid=5031}}
'''P2Y purinoceptor 6''' is a [[protein]] that in humans is encoded by the ''P2RY6'' [[gene]].<ref name="pmid8670200">{{cite journal | author = Communi D, Parmentier M, Boeynaems JM | title = Cloning, functional expression and tissue distribution of the human P2Y6 receptor | journal = Biochem Biophys Res Commun | volume = 222 | issue = 2 | pages = 303–8 | year = 1996 | month = Aug | pmid = 8670200 | pmc =  | doi = 10.1006/bbrc.1996.0739 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5031| accessdate = }}</ref>

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The product of this gene, P2Y<sub>6</sub>, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene.<ref name="entrez"/>
}}

==See also==
* [[P2Y receptor]]

==References==
{{reflist}}

==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2398 | title = P2Y Receptors: P2Y<sub>6</sub> | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Maier R, Glatz A, Mosbacher J, Bilbe G |title=Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. |journal=Biochem. Biophys. Res. Commun. |volume=237 |issue= 2 |pages= 297–302 |year= 1997 |pmid= 9268704 |doi= 10.1006/bbrc.1997.7135 }}
*{{cite journal  | author=Somers GR, Hammet F, Woollatt E, ''et al.'' |title=Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family. |journal=Genomics |volume=44 |issue= 1 |pages= 127–30 |year= 1997 |pmid= 9286708 |doi= 10.1006/geno.1997.4841 }}
*{{cite journal  | author=Maier R, Glatz A, Mosbacher J, Bilbe G |title=Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. |journal=Biochem. Biophys. Res. Commun. |volume=240 |issue= 2 |pages= 298–302 |year= 1997 |pmid= 9412455 |doi=  }}
*{{cite journal  | author=Pidlaoan LV, Jin J, Sandhu AK, ''et al.'' |title=Colocalization of P2Y2 and P2Y6 receptor genes at human chromosome 11q13.3-14.1. |journal=Somat. Cell Mol. Genet. |volume=23 |issue= 4 |pages= 291–6 |year= 1998 |pmid= 9542531 |doi=10.1007/BF02674420  }}
*{{cite journal  | author=Brinson AE, Harden TK |title=Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor. |journal=J. Biol. Chem. |volume=276 |issue= 15 |pages= 11939–48 |year= 2001 |pmid= 11114308 |doi= 10.1074/jbc.M009909200 }}
*{{cite journal  | author=Moore DJ, Chambers JK, Wahlin JP, ''et al.'' |title=Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study. |journal=Biochim. Biophys. Acta |volume=1521 |issue= 1-3 |pages= 107–19 |year= 2001 |pmid= 11690642 |doi=  }}
*{{cite journal  | author=Hou M, Harden TK, Kuhn CM, ''et al.'' |title=UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=282 |issue= 2 |pages= H784–92 |year= 2002 |pmid= 11788430 |doi= 10.1152/ajpheart.00997.2000 }}
*{{cite journal  | author=Loomis WH, Namiki S, Ostrom RS, ''et al.'' |title=Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation. |journal=J. Biol. Chem. |volume=278 |issue= 7 |pages= 4590–6 |year= 2003 |pmid= 12464620 |doi= 10.1074/jbc.M207868200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Kim SG, Soltysiak KA, Gao ZG, ''et al.'' |title=Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors. |journal=Biochem. Pharmacol. |volume=65 |issue= 6 |pages= 923–31 |year= 2003 |pmid= 12623123 |doi=10.1016/S0006-2952(02)01614-3  }}
*{{cite journal  | author=Schafer R, Sedehizade F, Welte T, Reiser G |title=ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=285 |issue= 2 |pages= L376–85 |year= 2003 |pmid= 12691958 |doi= 10.1152/ajplung.00447.2002 }}
*{{cite journal  | author=Lee H, Choi BH, Suh BC, ''et al.'' |title=Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells. |journal=J. Neurochem. |volume=85 |issue= 4 |pages= 1043–53 |year= 2003 |pmid= 12716436 |doi=10.1046/j.1471-4159.2003.01761.x  }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  | author=Wan D, Gong Y, Qin W, ''et al.'' |title=Large-scale cDNA transfection screening for genes related to cancer development and progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 44 |pages= 15724–9 |year= 2004 |pmid= 15498874 |doi= 10.1073/pnas.0404089101  | pmc=524842 }}
*{{cite journal  | author=Cox MA, Gomes B, Palmer K, ''et al.'' |title=The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP. |journal=Biochem. Biophys. Res. Commun. |volume=330 |issue= 2 |pages= 467–73 |year= 2005 |pmid= 15796906 |doi= 10.1016/j.bbrc.2005.03.004 }}
*{{cite journal  | author=Khine AA, Del Sorbo L, Vaschetto R, ''et al.'' |title=Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway. |journal=Blood |volume=107 |issue= 7 |pages= 2936–42 |year= 2006 |pmid= 16322472 |doi= 10.1182/blood-2005-06-2314 }}
*{{cite journal  | author=Wihlborg AK, Balogh J, Wang L, ''et al.'' |title=Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction. |journal=Circ. Res. |volume=98 |issue= 7 |pages= 970–6 |year= 2006 |pmid= 16543499 |doi= 10.1161/01.RES.0000217402.73402.cd }}
*{{cite journal  | author=Dulong S, Bernard K, Ehrenfeld J |title=Enhancement of P2Y6-induced Cl- secretion by IL-13 and modulation of SK4 channels activity in human bronchial cells. |journal=Cell. Physiol. Biochem. |volume=20 |issue= 5 |pages= 483–94 |year= 2007 |pmid= 17762175 |doi= 10.1159/000107532 }}
}}
{{refend}}

{{NLM content}}
{{G protein-coupled receptors}}

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[[Category:G protein coupled receptors]]


{{transmembranereceptor-stub}}

[[pt:P2RY6]]
[[Category:2Fix]]