Phenomorphan
From Self-sufficiency
| 140px | |
| Systematic (IUPAC) name | |
|---|---|
|
17-(2-phenylethyl)morphinan-3-ol | |
| Legal status | |
| Legal status |
|
| Identifiers | |
| CAS Number | 468-07-5 |
| ATC code | none |
| PubChem | CID 5362458 |
| Synonyms | (-)-3-hydroxy- N- (2-phenylethyl) morphinan |
| Chemical data | |
| Formula | C24H29NO |
| Molar mass | 347.493 g/mol[[Script error: No such module "String".]] |
Phenomorphan is an opioid analgesic. It is not currently used in medicine, but has similar side effects to other opiates, which include itching, nausea and respiratory depression.
Phenomorphan is a highly potent drug due to the N-phenethyl group which boosts affinity to the μ-opioid receptor, and so phenomorphan is around 10x more potent than levorphanol, which is itself 6-8x the potency of morphine. Other analogues where the N-(2-phenylethyl) group has been replaced by other aromatic rings are even more potent, with the N-(2-(2-furyl)ethyl) and the N-(2-(2-thienyl)ethyl) analogues being 60x and 45x stronger than levorphanol respectively.[1]
See also
- 14-Cinnamoyloxycodeinone
- 14-Phenylpropoxymetopon
- 7-PET
- N-Phenethylnormorphine
- N-Phenethyl-14-ethoxymetopon
- RAM-378
- Ro4-1539
References
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This pharmacology-related article is a stub. You can help ssf by expanding it. |
- ↑ Hellerbach J, Schnider O, Besendorf H, Pellmont B. Synthetic Analgesics. Part IIA. Morphinans. Pergamon Press, 1966.
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