Pravastatin

Pravastatin

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Systematic (IUPAC) name
(3R,5R)-3,5-dihydroxy-7-((1R,2S,6S,8R,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-heptanoic acid
Pharmacokinetic data
Protein binding	50%
Biological half-life	77 hours
Identifiers
CAS Number	81093-37-0
ATC code	C10AA03 (WHO)
PubChem	CID 54687
DrugBank	APRD00328
Chemical data
Formula	C23H36O7
Molar mass	424.528 g/mol[[]]
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Pravastatin (marketed as Pravachol or Selektine) is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease. Initially known as CS-514, it was originally identified in a bacterium called Nocardia autotrophica by researchers of the Sankyo Pharma Inc.. It is presently being marketed outside Japan by the pharmaceutical company Bristol-Myers Squibb.

The U.S. Food and Drug Administration approved generic pravastatin for sale in the United States for the first time on April 24, 2006. Generic pravastatin sodium tablets (10 mg, 20 mg and 40 mg) are manufactured by TEVA Pharmaceuticals in Kfar Sava, Israel.

External links

• Pravachol information from the National Institute of Health
• Package insert for Pravachol

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