Proguanil

From Self-sufficiency
Jump to: navigation, search
Proguanil
File:Proguanil Structural Formulae.png
File:Proguanil sf.png
Systematic (IUPAC) name
1-(4-chlorophenyl)-2-(N'-propan-2-ylcarbamimidoyl) guanidine
Pharmacokinetic data
Biological half-life ~20 h
Identifiers
CAS Number 500-92-5
ATC code P01BB01 (WHO)
PubChem CID 4923
DrugBank APRD00188
Chemical data
Formula C11H16ClN5
Molar mass 253.731 g/mol[[Script error: No such module "String".]]
  (verify)
Script error: No such module "TemplatePar".Expression error: Unexpected < operator.

Proguanil (chlorguanide, chloroguanide) is a prophylactic antimalarial drug.

Proguanil is effective against sporozoites.

Proguanil hydrochloride is marketed as Paludrine by AstraZeneca.

Mechanism

It works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells.

It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.

Combinations

Proguanil is usually taken in combination with another anti-malarial drug such as atovaquone[1] (e.g., in the drug Malarone) or chloroquine.[2]

Malarone has fewer side effects than mefloquine, but can be more expensive because it is taken daily.

Proguanil is taken with atovaquone for chloroquine-resistant and multidrug resistant strains of P. falciparum and P. vivax. Proguanil combined with atovaquone is sold under the tradename Malarone (GlaxoSmithKline)

Precautions

General precaution regarding Proguanil involves watching out for feelings of sullenness and anxiety to a level that is outside the ordinary, when taking over a period of several months.[citation needed] These may come on gradually and may not be immediately attributable to anything in particular.

References

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />

External links


de:Proguanil

es:Proguanil fr:Proguanil it:Proguanil ja:プログアニル pl:Prokwanil

pt:Proguanil
  1. Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  2. Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.