Stampidine

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Stampidine
File:Stampidine.png
Systematic (IUPAC) name
methyl N-((4-bromophenoxy){[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl]methoxy}phosphoryl)-D-alaninate
Identifiers
ATC code none
PubChem CID 469782
Chemical data
Formula C20H23BrN3O8P
Molar mass 544.289 g/mol[[Script error: No such module "String".]]
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Stampidine is an experimental nucleoside reverse transcriptase inhibitor (NRTI).

It is a derivative of d4T (stavudine, Zerit), and has been designed to avoid dependence on the rate limiting step of phosphorylation of stavudine to stavudine monophosphate. This is governed by the supply of thymidine kinase that is available, and stavudine is poorly phosphorylated to its monophosphate form in thymidine kinase-deficient cells. [1]

References

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  1. aidsmap.com | Stampidine