Sumanirole

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Sumanirole
File:Suminarole.png
Systematic (IUPAC) name
(R)-5,6-dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one
Identifiers
CAS Number 179386-43-7
179386-44-8 (maleate)
ATC code none
PubChem CID 9818479
ChemSpider 7994229
Chemical data
Formula C11H13N3O
Molar mass 203.240 g/mol[[Script error: No such module "String".]]
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Sumanirole (PNU-95,666) is a highly selective D2 receptor full agonist, the first of its kind to be discovered.[1][2][3] It was developed for the treatment of Parkinson's disease and restless leg syndrome. While it has never been approved for medical use [4][5] it is a highly valuable tool compound for basic research to identify neurobiological mechanisms that are based on a dopamine D2-linked (vs. D1, D3, D4, and D5-linked) mechanism of action. [3]

See also

References

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  1. Romero AG, et al. Synthesis of the selective D2 receptor agonist PNU-95666E from D-phenylalanine using a sequential oxidative cyclization strategy. Journal of Organic Chemistry. 1997; 62(19):6582.
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