View source for TAS2R1

{{PBB|geneid=50834}}
'''Taste receptor type 2 member 1''' is a [[protein]] that in humans is encoded by the ''TAS2R1'' [[gene]].<ref name="pmid10761934">{{cite journal | author = Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS | title = A novel family of mammalian taste receptors | journal = Cell | volume = 100 | issue = 6 | pages = 693–702 | year = 2000 | month = Apr | pmid = 10761934 | pmc =  | doi =10.1016/S0092-8674(00)80705-9  }}</ref><ref name="pmid10766242">{{cite journal | author = Matsunami H, Montmayeur JP, Buck LB | title = A family of candidate taste receptors in human and mouse | journal = Nature | volume = 404 | issue = 6778 | pages = 601–4 | year = 2000 | month = Apr | pmid = 10766242 | pmc =  | doi = 10.1038/35007072 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAS2R1 taste receptor, type 2, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50834| accessdate = }}</ref>

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil.<ref name="entrez">{{cite web | title = Entrez Gene: TAS2R1 taste receptor, type 2, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50834| accessdate = }}</ref>
}}

==See also==
* [[Taste receptor]]

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Kinnamon SC |title=A plethora of taste receptors. |journal=Neuron |volume=25 |issue= 3 |pages= 507–10 |year= 2000 |pmid= 10774719 |doi=10.1016/S0896-6273(00)81054-5  }}
*{{cite journal  | author=Margolskee RF |title=Molecular mechanisms of bitter and sweet taste transduction. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 1–4 |year= 2002 |pmid= 11696554 |doi= 10.1074/jbc.R100054200 }}
*{{cite journal  | author=Montmayeur JP, Matsunami H |title=Receptors for bitter and sweet taste. |journal=Curr. Opin. Neurobiol. |volume=12 |issue= 4 |pages= 366–71 |year= 2002 |pmid= 12139982 |doi=10.1016/S0959-4388(02)00345-8  }}
*{{cite journal  | author=Chandrashekar J, Mueller KL, Hoon MA, ''et al.'' |title=T2Rs function as bitter taste receptors. |journal=Cell |volume=100 |issue= 6 |pages= 703–11 |year= 2000 |pmid= 10761935 |doi=10.1016/S0092-8674(00)80706-0  }}
*{{cite journal  | author=Firestein S |title=The good taste of genomics. |journal=Nature |volume=404 |issue= 6778 |pages= 552–3 |year= 2000 |pmid= 10766221 |doi= 10.1038/35007167 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Zhang Y, Hoon MA, Chandrashekar J, ''et al.'' |title=Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. |journal=Cell |volume=112 |issue= 3 |pages= 293–301 |year= 2003 |pmid= 12581520 |doi=10.1016/S0092-8674(03)00071-0  }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  | author=Fischer A, Gilad Y, Man O, Pääbo S |title=Evolution of bitter taste receptors in humans and apes. |journal=Mol. Biol. Evol. |volume=22 |issue= 3 |pages= 432–6 |year= 2005 |pmid= 15496549 |doi= 10.1093/molbev/msi027 }}
*{{cite journal  | author=Go Y, Satta Y, Takenaka O, Takahata N |title=Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. |journal=Genetics |volume=170 |issue= 1 |pages= 313–26 |year= 2006 |pmid= 15744053 |doi= 10.1534/genetics.104.037523  | pmc=1449719 }}
}}
{{refend}}

{{transmembranereceptor-stub}}
{{NLM content}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]

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[[Category:2Fix]]