Thiocolchicoside

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Thiocolchicoside
File:Thiocolchicoside.png
Systematic (IUPAC) name
N-[(7S)-3-(beta-D-glucopyranosyloxy)-1,2-dimethoxy-10-(methylsulf​anyl)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
Clinical data
Routes of
administration
Oral, Topical, IM
Legal status
Legal status
  • ℞ (Prescription only)
Pharmacokinetic data
Bioavailability 25%[1]
Biological half-life 5-6 hours[1][2]
Identifiers
CAS Number 602-41-5
ATC code M03BX05 (WHO)
PubChem CID 72067
Chemical data
Formula C27H33NO10S
Molar mass 563.618 g/mol[[Script error: No such module "String".]]
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Thiocolchicoside (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects.[3][4][5][6] It acts as a competitive GABAA receptor antagonist and also inhibits glycine receptors with similar potency and nicotinic acetylcholine receptors to a much lesser extent.[7][8] It has powerful convulsant activity and should not be used in seizure-prone individuals.[9][10][11]

References

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  1. 1.0 1.1 Perucca E, Poitou P, Pifferi G (1995). "Comparative pharmacokinetics and bioavailability of two oral formulations of thiocolchicoside, a GABA-mimetic muscle relaxant drug, in normal volunteers". European Journal of Drug Metabolism and Pharmacokinetics. 20 (4): 301–5. PMID 8983937. 
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