U-69,593

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U-69,593
File:U-69593 structure.png
Systematic (IUPAC) name
N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]dec-8-yl]acetamide
Identifiers
CAS Number 96744-75-1
ATC code none
PubChem CID 105104
IUPHAR/BPS 1655
ChemSpider 94828
Chemical data
Formula C22H32N2O2
Molar mass 356.50 g/mol[[Script error: No such module "String".]]
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U-69,593 is a drug which acts as a potent and selective κ1-opioid receptor agonist.[1][2][3] In animal studies it has been shown to produce antinociception,[1][4][5], anti-inflammation,[6] anxiolysis (at low doses),[7][8][9] respiratory depression,[5] and diuresis,[10] while having little effect on gastrointestinal motility.[1] It also inhibits the peripheral, though not central secretion of oxytocin and vasopressin in rats.[11][12]

See also

References

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  1. 1.0 1.1 1.2 La Regina A, Petrillo P, Sbacchi M, Tavani A (1988). "Interaction of U-69,593 with mu-, alpha- and kappa-opioid binding sites and its analgesic and intestinal effects in rats". Life Sciences. 42 (3): 293–301. PMID 2826959. 
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