7-Hydroxymitragynine
| 7-Hydroxymitragynine | |
|---|---|
| 7-Hydroxymitragynine | |
| 7-Hydroxymitragynine | |
| style="background: #F8EABA; text-align: center;" colspan="2" | Properties | |
| Molecular formula | C23H30N2O5 |
| Molar mass | 414.49 g mol−1 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
7-Hydroxymitragynine, an indole, is an active alkaloid in the plant Mitragyna speciosa, commonly known as Kratom. It has opioid agonistic activity.[1] "The potency, calculated using pD (2) values, was 30- and 17-fold higher than that of mitragynine and morphine, respectively. Antagonism of naloxone on concentration-response curves for 7-hydroxymitragynine confirmed its opioid effect. These results suggest that the opioid effect of M. speciosa is mostly based on the activity of 7-hydroxymitragynine."[2]
7-Hydroxymitragynine is orally active in animals as an analgesic,[3] and produces normal opioid side effects including constipation[4] development of tolerance and withdrawal syndrome upon abstinence.[3] The O-acetyl ester, 7-acetoxymitragynine has also been reported and found to be an active μ-opioid agonist.[5]
See also
References
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