Active placebo
From Self-sufficiency
An active placebo is a placebo that mimics the common side effects of the drug under study.[1]
Nomenclature
According to a 1965 paper,[2] the term "fake placebo" (German: Kaschiertes Placebo) was suggested in a 1959 paper published in German.[3]
Example
Morphine and gabapentin are painkillers with the common side effects of sleepiness and dizziness. In a 2005 study assessing the effects of these painkillers on neuropathic pain, Lorazepam was chosen as an active placebo because it is not a painkiller but it does cause sleepiness and can cause dizziness.[4]
References
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<references />, or <references group="..." />- ↑ Jane Russell, quoted in about.com
- ↑ Park LC, Covi U (April 1965). "Nonblind placebo trial: an exploration of neurotic patients' responses to placebo when its inert content is disclosed" (PDF). Archives of General Psychiatry. 12: 336–45. PMID 14258363.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Gilron I, Bailey JM, Tu D, Holden RR, Weaver DF, Houlden RL (March 31, 2005). "Morphine, gabapentin, or their combination for neuropathic pain". N Engl J Med. 352 (13): 1324–34. PMID 15800228.
