Azaserine
From Self-sufficiency
| File:Azaserine.png | |
| Systematic (IUPAC) name | |
|---|---|
|
O-(2-Diazoacetyl)-L-serine | |
| Identifiers | |
| CAS Number | 115-02-6 |
| ATC code | none |
| PubChem | CID 5284344 |
| Chemical data | |
| Formula | C5H7N3O4 |
| Molar mass | 173.127 g/mol[[Script error: No such module "String".]] |
Azaserine is a carcinogen primarily used for researching pancreatic cancer in animal models. It is a glutamine analogue that irreversibly inhibits glutamine utilizing enzymes such as Gln: Phosphoribosyl Amidotransferase, which is involved in the biosynthesis of Inosine monophosphate (IMP). IMP is an important precursor to the purine nucleotides which include Adenosine monophosphate (AMP) and Guanosine monophosphate (GMP).
Further enzymes of purine and pyrimidine metabolism are inhibited as well. Therefore it was tested as anti-cancer drug by different authors in different indications (not only pancreatic cancer) in pre-clinical settings. Further glutamine analogues that were tested as anti-cancer drugs are DON and Acivicin.
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