Bemotrizinol
Bemotrizinol | |
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File:Bemotrizinol.png | |
2,2′-[6-(4-methoxyphenyl)- 1,3,5-triazine-2,4-diyl] bis{5-[(2-ethylhexyl)oxy]phenol} | |
Other names Tinosorb S Bis-ethylhexyloxyphenol methoxyphenyl triazine Anisotriazine | |
style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers | |
Abbreviations | BEMT |
CAS number | 187393-00-6 |
ChemSpider | 10645286 |
SMILES | Script error: No such module "collapsible list". |
InChI | Script error: No such module "collapsible list". |
InChI key | XVAMCHGMPYWHNL-UHFFFAOYAK |
style="background: #F8EABA; text-align: center;" colspan="2" | Properties | |
Molecular formula | C38H49N3O5 |
Molar mass | 627.81 g/mol |
(what is this?) (verify) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
Infobox references |
Bemotrizinol (INN[1][2]/USAN[3], INCI bis-ethylhexyloxyphenol methoxyphenyl triazine) is an oil-soluble organic compound that is added to sunscreens to absorb UV rays. It is marketed as Tinosorb S by BASF and as Escalol S by International Specialty Products.
Bemotrizinol is a broad-spectrum UV absorber, absorbing UVB as well as UVA rays. It has two absorption peaks, 310 and 340 nm.[4] It is highly photostable. Even after 50 MEDs (minimal erythemal doses), 98.4% remains intact. It helps prevent the photodegradation of other sunscreen actives like avobenzone.[5]
Bemotrizinol has strong synergistic effects on the SPF when formulated with bisoctrizole, ethylhexyl triazone or iscotrizinol.[6] It is the most effective UV absorber available measured by SPF, based on the maximum concentration permitted by European legislation.[7]
Bemotrizinol is not approved by the United States Food and Drug Administration, but is approved in the European Union since the year 2000[8] and other parts of the world, including Australia.[9][10]
Unlike some other organic sunscreen actives, it shows no estrogenic effects in vitro.[11]
References
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External links
- ↑ http://whqlibdoc.who.int/druginfo/18_4_2004_INN92.pdf
- ↑ http://whqlibdoc.who.int/druginfo/INN_2005_list54.pdf
- ↑ http://www.ama-assn.org/ama1/pub/upload/mm/365/bemotrizinol.doc
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ http://www.ciba.com/tinosorb-s_brochure.pdf
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ .SpringerLink - Journal Article
- ↑ NEW-WAVE SUNSCREENS: Active ingredient makers are frustrated by the long list of sunscreens and UV-A testing protocols that are still awaiting FDA decisions, Chemical & Engineering News, April 11, 2005, Volume 83, Number 15, pp. 18–22. Online version
- ↑ Australian Regulatory Guidelines for OTC Medicines - Chapter 10
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.