Bemotrizinol

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Bemotrizinol
File:Bemotrizinol.png
style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers
Abbreviations BEMT
CAS number 187393-00-6 YesY
ChemSpider 10645286
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InChI key XVAMCHGMPYWHNL-UHFFFAOYAK
style="background: #F8EABA; text-align: center;" colspan="2" | Properties
Molecular formula C38H49N3O5
Molar mass 627.81 g/mol
 YesY (what is this?)  (verify)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Bemotrizinol (INN[1][2]/USAN[3], INCI bis-ethylhexyloxyphenol methoxyphenyl triazine) is an oil-soluble organic compound that is added to sunscreens to absorb UV rays. It is marketed as Tinosorb S by BASF and as Escalol S by International Specialty Products.

Bemotrizinol is a broad-spectrum UV absorber, absorbing UVB as well as UVA rays. It has two absorption peaks, 310 and 340 nm.[4] It is highly photostable. Even after 50 MEDs (minimal erythemal doses), 98.4% remains intact. It helps prevent the photodegradation of other sunscreen actives like avobenzone.[5]

Bemotrizinol has strong synergistic effects on the SPF when formulated with bisoctrizole, ethylhexyl triazone or iscotrizinol.[6] It is the most effective UV absorber available measured by SPF, based on the maximum concentration permitted by European legislation.[7]

Bemotrizinol is not approved by the United States Food and Drug Administration, but is approved in the European Union since the year 2000[8] and other parts of the world, including Australia.[9][10]

Unlike some other organic sunscreen actives, it shows no estrogenic effects in vitro.[11]

References

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External links

  1. http://whqlibdoc.who.int/druginfo/18_4_2004_INN92.pdf
  2. http://whqlibdoc.who.int/druginfo/INN_2005_list54.pdf
  3. http://www.ama-assn.org/ama1/pub/upload/mm/365/bemotrizinol.doc
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  6. http://www.ciba.com/tinosorb-s_brochure.pdf
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  8. .SpringerLink - Journal Article
  9. NEW-WAVE SUNSCREENS: Active ingredient makers are frustrated by the long list of sunscreens and UV-A testing protocols that are still awaiting FDA decisions, Chemical & Engineering News, April 11, 2005, Volume 83, Number 15, pp. 18–22. Online version
  10. Australian Regulatory Guidelines for OTC Medicines - Chapter 10
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