Bromfenac

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Bromfenac
File:Bromfenac.png
Systematic (IUPAC) name
2-[2-amino-3-(4-bromobenzoyl)phenyl]acetic acid
Clinical data
Pregnancy
category
  • C
Routes of
administration
Oral (discontinued)
ophthalmic
Legal status
Legal status
Identifiers
CAS Number 91714-94-2
ATC code S01BC11 (WHO)
PubChem CID 60726
Chemical data
Formula C15H12BrNO3
Molar mass 334.16g/mol[[Script error: No such module "String".]]
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Bromfenac is a non-steroidal anti-inflammatory drug (NSAID) marketed in the US as an ophthalmic solution (brand name Xibrom) by Ista for short-term, local use.

It was originally introduced as a prescription capsule (brand name Duract) by Wyeth=-Ayerst, but this form of the drug was withdrawn from the US market and discontinued due to side effects of systemic, long-term administration.

Chemistry

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Walsh, David A.; Moran, H. Wayne; Shamblee, Dwight A.; Uwaydah, Ibrahim M.; Welstead, William J.; Sancilio, Lawrence F.; Dannenburg, Warren N. (1984). "Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogs". Journal of Medicinal Chemistry. 27 (11): 1379. doi:10.1021/jm00377a001. PMID 6436487. 

External links