Brushfield spots
Brushfield spots are small white or grayish/brown spots on the periphery of the iris in the human eye due to aggregation of connective tissue, a normal iris element. These spots are normal in children (Kunkmann-Wolffian bodies) but are also a feature of the chromosomal disorder Down syndrome. They occur in 35-78% of newborn infants with Down syndrome.[1] They are much more likely to occur in Down syndrome children of the Caucasian race than children of Asian heritage.[2] Brushfield spots are named after the physician, Thomas Brushfield, who first described them in his 1924 M.D. thesis.[3]
They are focal areas of stromal hyperplasia, surrounded by relative hypoplasia and are more common in patients with lightly pigmented irises.
References
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es:Manchas de Brushfield pl:Plamki Brushfielda pt:Manchas de Brushfield
sv:Brushfields prickar- ↑ Sanez, R.B. (January 1999), "Primary care of infants and young children with down syndrome.", American Family Physician, 59 (2)
- ↑ Kim, J.H.; et al. (November 2002), "Characteristic ocular findings in Asian children with Down syndrome.", Nature, 16 (6)
- ↑ Hugh R.E. Wallis. The Significance of Brushfield's Spots in the Diagnosis of Mongolism in Infancy. Arch Dis Child. 1951 December; 26 (130): 495-500. Retrieved on 21 March 2009.
