Cherry-red spot

A cherry-red spot is a finding in the macula of the eye in a variety of lipid storage disorders and in central retinal artery occlusion. It describes the appearance of a small circular choroid shape as seen through the fovea centralis. Its appearance is due to a relative transparency of the macula; storage disorders cause the accumulation of storage material within the cell layers of the retina, however, the macula, which is relatively devoid of cellular layers, does not build up this material, and thus allows the eye to cell through the macula to the red choroid below.

The sign was first described by Warren Tay, founding member of the British Ophthalmological Society, in 1881, with reference to a patient with Tay-Sachs disease.

The cherry red spot is seen in central retinal artery occlusion, appearing several hours after the blockage of the retinal artery occurs. The cherry red spot is seen because the macula receives its blood supply from the choroid artery while the surrounding retina is pale due to retinal artery infarction. It is also seen in several other conditions, classically Tay-Sachs Disease, but also in Niemann-Pick Disease, Sandhoff disease, and mucolipidosis.

Differential Diagnosis of Cherry Red Spot at Macula

1. Metabolic Storage Diseases:
   1. Mucopolysaccharidosis
   2. Hurler's disease
   3. Tay-Sachs disease
   4. MPS VII
   5. Farber's disease
   6. GM1 gangliosidosis
   7. Juvenileeroid
   8. Niemann Pick's disease
   9. Sandoff's disease
   10. Goldberg syndrome
   11. Lysosomal Storage Diseases
2. Congenital Developmental Diseases : Amaurosis, congenital, Leber's
3. Hereditary/ Familial:
   1. Hallervorden Spatz disease
   2. leukodystrophy, Krabbe's
4. Degenerative: Metachromatic leukodystrophy
5. Vascular: central retinal artery occlusion
6. Drugs:
   1. Quinine toxicity
   2. Dapsone toxicity
7. Poisoning:
   1. Carbon monoxide
   2. Methanol

See also

• lipid storage disease