Chloroethylnorapomorphine

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Chloroethylnorapomorphine
File:Chloroethylnorapomorphine.png
style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers
CAS number 75946-94-0
PubChem 156376
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style="background: #F8EABA; text-align: center;" colspan="2" | Properties
Molecular formula C18H18ClNO2
Molar mass 315.79 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Chloroethylnorapomorphine is a chemical once thought to be an irreversible dopamine D2 receptor antagonist;[1][2] however, it was later proved to be reversible.[3]

References

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  1. Cohen SA, Neumeyer JL. Aporphines. 50. Kinetics of solvolysis of N-(2-chloroethyl)norapomorphine, an irreversible dopamine receptor antagonist. Journal of Medicinal Chemistry. 1983 Oct;26(10):1348-53. PMID 6620296
  2. Guan JH, Neumeyer JL, Filer CN, Ahern DG, Lilly L, Watanabe M, Grigoriadis D, Seeman P. Aporphines. 58. N-(2-chloroethyl) [8,9-2H]norapomorphine, an irreversible ligand for dopamine receptors: synthesis and application. Journal of Medicinal Chemistry. 1984 Jun;27(6):806-10. PMID 6737423
  3. Lehmann, J; Langer, SZ (1982). "Dopamine autoreceptors differ pharmacologically from postsynaptic dopamine receptors: Effects of (−)-N-(2-chloroethyl)-norapomorphine". European Journal of Pharmacology. 77 (1): 85. doi:10.1016/0014-2999(82)90542-8. PMID 7060630.