Chloroethylnorapomorphine
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| Chloroethylnorapomorphine | |
|---|---|
| File:Chloroethylnorapomorphine.png | |
| 6-(2-Chloro-ethyl)-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol | |
| Other names (-)-N-(2-Chloroethyl)-norapomorphine | |
| style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers | |
| CAS number | 75946-94-0 |
| PubChem | 156376 |
| SMILES | Script error: No such module "collapsible list". |
| style="background: #F8EABA; text-align: center;" colspan="2" | Properties | |
| Molecular formula | C18H18ClNO2 |
| Molar mass | 315.79 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
Chloroethylnorapomorphine is a chemical once thought to be an irreversible dopamine D2 receptor antagonist;[1][2] however, it was later proved to be reversible.[3]
References
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- ↑ Cohen SA, Neumeyer JL. Aporphines. 50. Kinetics of solvolysis of N-(2-chloroethyl)norapomorphine, an irreversible dopamine receptor antagonist. Journal of Medicinal Chemistry. 1983 Oct;26(10):1348-53. PMID 6620296
- ↑ Guan JH, Neumeyer JL, Filer CN, Ahern DG, Lilly L, Watanabe M, Grigoriadis D, Seeman P. Aporphines. 58. N-(2-chloroethyl) [8,9-2H]norapomorphine, an irreversible ligand for dopamine receptors: synthesis and application. Journal of Medicinal Chemistry. 1984 Jun;27(6):806-10. PMID 6737423
- ↑ Lehmann, J; Langer, SZ (1982). "Dopamine autoreceptors differ pharmacologically from postsynaptic dopamine receptors: Effects of (−)-N-(2-chloroethyl)-norapomorphine". European Journal of Pharmacology. 77 (1): 85. doi:10.1016/0014-2999(82)90542-8. PMID 7060630.
