Cords of Billroth
The Cords of Billroth (also known as splenic cords or red pulp cords) are found in the red pulp of the spleen between the sinusoids, consisting of fibrils and connective tissue cells with a large population of monocytes and macrophages. They contain half the body's monocytes as a reserve that after tissue injury can move in and aid wound healing.[1]
Erythrocytes pass through the cords of Billroth before entering the sinusoids. The passage into the sinusoids may be seen as a bottleneck, where erythrocytes need to be flexible in order to pass through. In disorders of erythrocyte shape and/or flexibility, such as hereditary spherocytosis, erythrocytes fail to pass through and get phagocytosed, causing extravascular hemolysis. [2]
Eponym
They are named for Theodor Billroth, Austrian surgeon.[3]
References
- ↑ Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo J-L, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ. (2009). Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites. Science, 325: 612-616. doi:10.1126/science.1175202
- ↑ Chapter 12, page 425 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.
- ↑ synd/2727 at Who Named It?
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<references />, or <references group="..." />External links
- Anatomy Atlases - Microscopic Anatomy, plate 09.175 - "Spleen: Red Pulp"
- Histology at BU 07803loa - "Lymphoid Tissues and Organs: splenic reticulum"
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