Cromakalim

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Cromakalim
File:Cromakalim.svg
Systematic (IUPAC) name
(3R,4S)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile
Identifiers
CAS Number 94470-67-4
ATC code none
PubChem CID 71191
ChemSpider 64327
Chemical data
Formula C16H18N2O3
Molar mass 286.32 g/mol[[Script error: No such module "String".]]
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Cromakalim (INN) is a potassium channel-opening vasodilator. The active isomer is levcromakalim. It acts on ATP-sensitive potassium channels and so causes membrane hyperpolarization. It can be used to treat hypertension as it will relax vascular smooth muscle to lower blood pressure. Hyperpolarisation of smooth muscle cell membranes pulls their membrane potential away from the threshold, so making it more difficult to excite them and thereby cause contraction.


it:Cromakalim