Cyclic AMP receptors
| Slime mold cyclic AMP receptor | |
|---|---|
| Identifiers | |
| Symbol | Dicty_CAR |
| Pfam | PF05462 |
| Pfam clan | CL0192 |
| InterPro | IPR000848 |
| PROSITE | PDOC00691 |
Cyclic AMP receptors from slime molds are a distinct family of G-protein coupled receptors. These receptors control development in Dictyostelium discoideum.
The cyclic AMP receptors coordinate aggregation of individual cells into a multicellular organism, and regulate the expression of a large number of developmentally-regulated genes[1][2][3]. The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However, while a similar 3D framework has been proposed to account for this, there is no significant sequence similarity between these families: the cAMP receptors thus bear their own unique '7TM' signature.
References
Cite error: Invalid <references> tag;
parameter "group" is allowed only.
<references />, or <references group="..." />| 40x30px | This transmembrane receptor-related article is a stub. You can help ssf by expanding it. |
- ↑ Devreotes PN, Kimmel AR, Johnson RL, Klein PS, Sun TJ, Saxe III CL (1988). "A chemoattractant receptor controls development in Dictyostelium discoideum". Science. 241 (4872): 1467–1472. doi:10.1126/science.3047871. PMID 3047871.
- ↑ Ginsburg GT, Louis JM, Johnson R, Devreotes PN, Kimmel AR, Saxe III CL (1993). "CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum". Genes Dev. 7 (2): 262–272. doi:10.1101/gad.7.2.262. PMID 8436297.
- ↑ Devreotes PN, Kimmel AR, Johnson RL, Gollop R, Saxe III CL (1993). "Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development". Genes Dev. 7 (2): 273–282. doi:10.1101/gad.7.2.273. PMID 8382181.
