Dexrazoxane

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Dexrazoxane
File:Dexrazoxane.svg
Systematic (IUPAC) name
4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
Identifiers
CAS Number 24584-09-6
ATC code V03AF02 (WHO)
PubChem CID 71384
DrugBank APRD00090
ChemSpider 64479
Chemical data
Formula C11H16N4O4
Molar mass 268.269 g/mol[[Script error: No such module "String".]]
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Dexrazoxane hydrochloride (Zinecard by Pfizer in USA and Canada; Cardioxane by Novartis for EU and other countries) is a cardioprotective agent.

Uses

It is used to protect the heart against the cardiotoxic side effects of anthracyclines,[1] such as doxorubicin.[2]

FDA has also approved a dexrazoxane hydrochloride drug, brand name Totect or Savene (developed by TopoTarget), for use as a treatment of extravasation resulting from IV anthracycline chemotherapy.[3][4] Extravasation is an adverse event in which chemotherapies containing anthracylines leak out of the blood vessel and necrotize the surrounding tissue.

Mechanism

As a derivative of EDTA, dexrazoxane chelates iron, but the precise mechanism by which it protects the heart is not known.

References

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  3. Totect label on FDA's website
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