Ditolylguanidine
From Self-sufficiency
| 200px | |
| Systematic (IUPAC) name | |
|---|---|
|
1,2-bis(2-methylphenyl)guanidine | |
| Identifiers | |
| CAS Number | 97-39-2 |
| ATC code | none |
| PubChem | CID 7333 |
| Chemical data | |
| Formula | C15H17N3 |
| Molar mass | 239.316 g/mol[[Script error: No such module "String".]] |
Ditolylguanidine is a sigma receptor agonist.[1] It is selective for sigma receptors, but non-selective between the two sigma receptor subtypes, binding to both σ1 and σ2 with equal affinity.[2] It has neuroprotective[3] and antidepressant effects,[4] and potentiates the effects of NMDA antagonists.[5]
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References
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Glennon RA. Pharmacophore identification for sigma-1 (sigma1) receptor binding: application of the "deconstruction-reconstruction-elaboration" approach. Mini Reviews in Medicinal Chemistry. 2005 Oct;5(10):927-40. PMID 16250835
- ↑ Katnik C, Guerrero WR, Pennypacker KR, Herrera Y, Cuevas J. Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia. Journal of Pharmacology and Experimental Therapeutics. 2006 Dec;319(3):1355-65. PMID 16988055
- ↑ Skuza G, Rogóz Z. Sigma1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats. Polish Journal of Pharmacology. 2003 Nov-Dec;55(6):1149-52. PMID 14730114
- ↑ Monnet FP, Morin-Surun MP, Leger J, Combettes L. Protein kinase C-dependent potentiation of intracellular calcium influx by sigma1 receptor agonists in rat hippocampal neurons. Journal of Pharmacology and Experimental Therapeutics. 2003 Nov;307(2):705-12. PMID 12975497
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