E7080

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E7080
File:E7080 structure.svg
Systematic (IUPAC) name
4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxy-quinoline-6-carboxamide
Legal status
Legal status
  • investigational
Identifiers
CAS Number 417716-92-8
ATC code none
PubChem CID 9823820
Chemical data
Formula C21H19ClN4O4
Molar mass 426.85296 g/mol[[Script error: No such module "String".]]
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E7080 is a multi-kinase inhibitor. It is an inhibitor of both VEGFR2 and VEGFR3 kinase. It has been evaluated in vitro (pre-clinical) for anti-cancer effects.[1]

Clinical trials

It has had promising results from a phase I clinical trial in 2006[2] and is being tested in several Phase I and II trials as of October 2009, for example against hepatocellular carcinoma[3] and non-small cell lung carcinoma[4].

References

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  1. ↑ Matsui, J. (2008). "Multi-Kinase Inhibitor E7080 Suppresses Lymph Node and Lung Metastases of Human Mammary Breast Tumor MDA-MB-231 via Inhibition of Vascular Endothelial Growth Factor-Receptor (VEGF-R) 2 and VEGF-R3 Kinase". Clinical Cancer Research. 14: 5459. doi:10.1158/1078-0432.CCR-07-5270.  |first2= missing |last2= in Authors list (help); |first3= missing |last3= in Authors list (help); |first4= missing |last4= in Authors list (help); |first5= missing |last5= in Authors list (help); |first6= missing |last6= in Authors list (help)
  2. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  3. ↑ ClinicalTrials.gov NCT00946153
  4. ↑ ClinicalTrials.gov NCT00832819
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