Edaravone
File:Edaravone.png | |
Systematic (IUPAC) name | |
---|---|
5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one | |
Clinical data | |
Routes of administration | Oral |
Legal status | |
Legal status |
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Identifiers | |
CAS Number | 89-25-8 |
ATC code | none |
PubChem | CID 4021 |
ChemSpider | 3881 |
Synonyms | MCI-186 |
Chemical data | |
Formula | C10H10N2O |
Molar mass | 174.20 g/mol[[Script error: No such module "String".]] |
Script error: No such module "collapsible list". |
Edaravone (Radicut) is a neuroprotective agent used for the purpose of aiding neurological recovery following acute brain ischemia and subsequent cerebral infarction.[1] It acts as a potent antioxidant and strongly scavenges free radicals, protecting against oxidative stress and neuronal apoptosis.[2][3][4] It has been marketed solely in Japan by Mitsubishi Pharma since 2001.[1]
Edaravone has been shown to attenuate methamphetamine- and 6-OHDA-induced dopaminergic neurotoxicity in the striatum and substantia nigra, and does not affect methamphetamine-induced dopamine release or hyperthermia.[5][6] It has also been demonstrated to protect against MPTP-mediated dopaminergic neurotoxicity to the substantia nigra, though notably not to the striatum.[7][8][9]
References
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- ↑ 1.0 1.1 Doherty, Annette M. (2002). Annual Reports in Medicinal Chemistry, Volume 37 (Annual Reports in Medicinal Chemistry). Boston: Academic Press. ISBN 0-12-040537-7.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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- ↑ Yoshida H, Yanai H, Namiki Y, Fukatsu-Sasaki K, Furutani N, Tada N (2006). "Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury". CNS Drug Reviews. 12 (1): 9–20. doi:10.1111/j.1527-3458.2006.00009.x. PMID 16834755.
- ↑ Yuan WJ, Yasuhara T, Shingo T; et al. (2008). "Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons". BMC Neuroscience. 9: 75. doi:10.1186/1471-2202-9-75. PMC 2533664 Freely accessible. PMID 18671880.
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