Epoxygenase
From Self-sufficiency
Epoxygenase is an enzyme that produces hydroxyeicosatetraenoic acids (HETEs) and epoxyeicosatrienoic acids (EETs) from arachidonic acid, causing effects such as cell proliferation and decrease in cyclooxygenase activity. [1]
Contents
Effects
HETEs
Hydroxyeicosatetraenoic acids cause:
- In mononuclear leukocytes: Cell proliferation, calcium release from intracellular stores and decreased TNF production. [1]
- Suggested to destruct beta cells, contributing to type 1 diabetes [1]
- In endothelial cells: Decreased release of fibrinolytic factors and decrease binding of antithrombin[1]
- Cell proliferation and migration of vascular smooth muscle cells, suggesting contribution to atherosclerosis.[1]
- Vasoconstriction, increased myogenic mechanism sensitivity in renal and cerebral arteries.[1]
EETs
Further information: Epoxyeicosatrienoic acid
Generally, EETs cause:
- Calcium release from intracellular stores[1]
- Increased sodium-hydrogen antiporter activity[1]
- Increased cell proliferation[1]
- Decreased cyclooxygenase activity[1]
References
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