Fosmidomycin

Fosmidomycin

File:Fosmidomycin.svg
Systematic (IUPAC) name
3-[Formyl(hydroxy)amino]propoylphosphonic acid
Identifiers
CAS Number	66508-53-0
ATC code	none
PubChem	CID 572
DrugBank	EXPT01469
ChemSpider	555
Chemical data
Formula	C4H10NO5P
Molar mass	183.100 g/mol[[]]

Fosmidomycin is an antibiotic that specifically inhibits DXP reductoisomerase, a key enzyme in the non-mevalonate pathway. It is a structural analogue of 2-C-methyl-D-erythrose 4-phosphate. It inhibits the E. coli enzyme with a KI value of 38 nM (4), MTB at 80 nM, and the Francisella enzyme at 99 nM .

The discovery of the non-mevalonate pathway in malaria parasites has indicated the use of fosmidomycin and other such inhibitors as anti-malarial drugs. Indeed, fosmidomycin has been tested in combination treatment with clindamycin for treatment of malaria with favorable results. It has been shown that an increase in copy number of the target enzyme (DXP reductoisomerase) correlates with in vitro fosmidomycin resistance in the lethal malaria parasite, Plasmodium falciparum.

See also

• Fosfomycin

References

de:Fosmidomycin