Gabexate
From Self-sufficiency
| 275px | |
| Systematic (IUPAC) name | |
|---|---|
|
ethyl 4-[6-(diaminomethylideneamino)hexanoyloxy]benzoate | |
| Identifiers | |
| CAS Number | 39492-01-8 |
| ATC code | none |
| PubChem | CID 3447 |
| Chemical data | |
| Formula | C16H23N3O4 |
| Molar mass | 311.37 g/mol[[Script error: No such module "String".]] |
Gabexate is a serine protease inhibitor which is used therapeutically (as gabexate mesilate) in the treatment of pancreatitis, disseminated intravascular coagulation[1], and as a regional anticoagulant for haemodialysis.[2]
References
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- ↑ Yuksel M, Okajima K, Uchiba M, Okabe H (2003). "Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappaB and activator protein-1 in human monocytes" (PDF). J. Pharmacol. Exp. Ther. 305 (1): 298–305. doi:10.1124/jpet.102.041988. PMID 12649382.
- ↑ Cavallini G, Tittobello A, Frulloni L, Masci E, Mariana A, Di Francesco V (1996). "Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. Gabexate in digestive endoscopy--Italian Group" (PDF). N. Engl. J. Med. 335 (13): 919–23. doi:10.1056/NEJM199609263351302. PMID 8786777.
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