HTR3B

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5-hydroxytryptamine (serotonin) receptor 3B
Identifiers
Symbol	HTR3B
External IDs	OMIM: 604654 MGI: 1861899 HomoloGene: 38131 IUPHAR: 5-HT3B GeneCards: HTR3B Gene
Gene Ontology Molecular function • nicotinic acetylcholine-activated cation-selective channel activity • serotonin receptor activity • extracellular ligand-gated ion channel activity • ion channel activity • serotonin-activated cation-selective channel activity • neurotransmitter receptor activity Cellular component • membrane • integral to plasma membrane • integral to membrane • plasma membrane • postsynaptic membrane Biological process • transport • synaptic transmission • ion transport • serotonin receptor signaling pathway Sources: Amigo / EGO
Orthologs
Species	Human	Mouse
Entrez	9177	57014
Ensembl	ENSG00000149305	ENSMUSG00000008590
UniProt	O95264	Q9JHJ5
RefSeq (mRNA)	NM_006028	NM_020274
RefSeq (protein)	NP_006019	NP_064670
Location (UCSC)	Chr 11: 113.28 - 113.32 Mb	Chr 9: 48.74 - 48.77 Mb
PubMed search	[1]	[2]

5-hydroxytryptamine (serotonin) receptor 3B, also known as HTR3B, is a human gene. The protein encoded by this gene is a subunit of the 5-HT3 receptor.

Further reading

• Need AC, Keefe RS, Ge D; et al. (2009). "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis". Eur. J. Hum. Genet. 17 (7): 946–57. doi:10.1038/ejhg.2008.264. PMID 19156168. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meineke C, Tzvetkov MV, Bokelmann K; et al. (2008). "Functional characterization of a -100_-102delAAG deletion-insertion polymorphism in the promoter region of the HTR3B gene". Pharmacogenet. Genomics. 18 (3): 219–30. doi:10.1097/FPC.0b013e3282f51092. PMID 18300944. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Levran O, Londono D, O'Hara K; et al. (2008). "Genetic susceptibility to heroin addiction: a candidate gene association study". Genes, Brain and Behavior. 7 (7): 720–9. doi:10.1111/j.1601-183X.2008.00410.x. PMC 2885890 Freely accessible. PMID 18518925. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kato M, Fukuda T, Wakeno M; et al. (2006). "Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients". Neuropsychobiology. 53 (4): 186–95. doi:10.1159/000094727. PMID 16874005. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu XQ, Peoples RW (2008). "The 5-HT3B subunit confers spontaneous channel opening and altered ligand properties of the 5-HT3 receptor". J. Biol. Chem. 283 (11): 6826–31. doi:10.1074/jbc.M707571200. PMID 18187416. 
• Krzywkowski K, Davies PA, Feinberg-Zadek PL; et al. (2008). "High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor". Proc. Natl. Acad. Sci. U.S.A. 105 (2): 722–7. doi:10.1073/pnas.0708454105. PMC 2206603 Freely accessible. PMID 18184810. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ji X, Takahashi N, Branko A; et al. (2008). "An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population". Nagoya journal of medical science. 70 (1-2): 11–7. PMID 18807291. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kato M, Serretti A (2008). "Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder". Mol. Psychiatry. 15 (5): HASH(0x155b370). doi:10.1038/mp.2008.116. PMID 18982004. 
• Walstab J, Hammer C, Bönisch H; et al. (2008). "Naturally occurring variants in the HTR3B gene significantly alter properties of human heteromeric 5-hydroxytryptamine-3A/B receptors". Pharmacogenet. Genomics. 18 (9): 793–802. doi:10.1097/FPC.0b013e3283050117. PMID 18698232. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yosifova A, Mushiroda T, Stoianov D; et al. (2009). "Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population". Journal of affective disorders. 117 (1-2): 87–97. doi:10.1016/j.jad.2008.12.021. PMID 19328558. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tzvetkov MV, Meineke C, Oetjen E; et al. (2007). "Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine". Gene. 386 (1-2): 52–62. doi:10.1016/j.gene.2006.08.002. PMID 17010535. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oades RD, Lasky-Su J, Christiansen H; et al. (2008). "The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis". Behavioral and brain functions : BBF. 4: 48. doi:10.1186/1744-9081-4-48. PMC 2577091 Freely accessible. PMID 18937842. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fasching PA, Kollmannsberger B, Strissel PL; et al. (2008). "Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy". J. Cancer Res. Clin. Oncol. 134 (10): 1079–86. doi:10.1007/s00432-008-0387-1. PMID 18389280. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka M, Kobayashi D, Murakami Y; et al. (2008). "Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea". Int. J. Neuropsychopharmacol. 11 (2): 261–7. doi:10.1017/S1461145707007985. PMID 17697394. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gratacòs M, Costas J, de Cid R; et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Krzywkowski K, Davies PA, Irving AJ; et al. (2008). "Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling". Pharmacogenet. Genomics. 18 (12): 1027–40. doi:10.1097/FPC.0b013e328310f950. PMID 19008750. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Smith AK, Dimulescu I, Falkenberg VR; et al. (2008). "Genetic evaluation of the serotonergic system in chronic fatigue syndrome". Psychoneuroendocrinology. 33 (2): 188–97. doi:10.1016/j.psyneuen.2007.11.001. PMID 18079067. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de Krom M, Staal WG, Ophoff RA; et al. (2009). "A common variant in DRD3 receptor is associated with autism spectrum disorder". Biol. Psychiatry. 65 (7): 625–30. doi:10.1016/j.biopsych.2008.09.035. PMID 19058789. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ducci F, Enoch MA, Yuan Q; et al. (2009). "HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power--an intermediate phenotype for alcoholism and co-morbid behaviors". Alcohol. 43 (1): 73–84. doi:10.1016/j.alcohol.2008.09.005. PMC 2754808 Freely accessible. PMID 19185213. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• MeSH HTR3B+protein,+human