Halofuginone
| File:Halofuginone.png | |
| Systematic (IUPAC) name | |
|---|---|
|
7-Bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4-quinazolinone | |
| Identifiers | |
| CAS Number | 55837-20-2 |
| ATCvet code | QP51AX08 (WHO) |
| PubChem | CID 62891 |
| Chemical data | |
| Formula | C16H17BrClN3O3 |
| Molar mass | 414.68 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
Halofuginone is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa febrifuga (Chang Shan).[1] Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S. Food and Drug Administration.[2]
Halofuginone inhibits the development of T helper 17 cells, immune cells that play an important players in autoimmune disease, but it does not affect other kinds of T cells which involved in normal immune function.[3] Halofuginone therefore has potential for the treatment of autoimmune disorders.[4]
Halofuginine is also an inhibitor of collagen type I gene expression and as a consequence it may inhibit tumor cell growth.[1]
References
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<references />, or <references group="..." />- ↑ 1.0 1.1 Halofuginone hydrobromide, NCI Drug Dictionary
- ↑ Halofuginone Receives FDA Orphan Drug Status For Scleroderma, March 10, 2000
- ↑ Sundrud, M. S.; Koralov, S. B.; Feuerer, M.; Calado, D. P.; Kozhaya, A. E.; Rhule-Smith, A.; Lefebvre, R. E.; Unutmaz, D.; Mazitschek, R. (2009). "Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response". Science. 324 (5932): 1334. doi:10.1126/science.1172638. PMC 2803727 Freely accessible. PMID 19498172.
- ↑ A new lead for autoimmune disease: A small-molecule drug inhibits Th17 cells, eases symptoms in mouse model, June 4, 2009
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