Hesperidin

Hesperidin
File:Hesperidin structure.svg
IUPAC name (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one
style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers
CAS number	520-26-3 Y
PubChem	10621
SMILES
style="background: #F8EABA; text-align: center;" colspan="2" | Properties
Molecular formula	C28H34O15
Molar mass	610.56 g mol−1
Exact mass	610.18977
Y (what is this?)  (verify) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Hesperidin is a flavanone glycoside (flavonoid) (C₂₈H₃₄O₁₅) found abundantly in citrus fruits. Its aglycone form is called hesperetin. Its name is derived from the Hesperides nymphs of Greek mythology. Hesperidin is believed to play a role in plant defense. It acts as an antioxidant according to in vitro studies. In human nutrition, it contributes to the integrity of the blood vessels.

Various preliminary studies reveal novel pharmaceutical properties. Hesperidin reduced cholesterol and blood pressure in rats. In a mouse study, large doses of the glucoside hesperidin decreased bone density loss. Another animal study showed protective effects against sepsis. Hesperidin has anti-inflammatory effects.. Hesperidin is also a sedative, possibly acting through opioid or adenosine receptors.

Some in vitro results applied only to the aglucone form. Hesperidin also showed the ability to penetrate the blood brain barrier in an in vitro model.

References

de:Hesperidin ja:ヘスペリジン