This page is a medical information page -- A quick-reference of prescription, dosage, and other data for medical professionals and others interested in ascertaining the applicability/effectiveness of their treatment.
| General classification
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- Antihistamine -- Competitive antagonist of histamine, H1 histamine receptor and antiemetic, anxiolytic.
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| Prescriptive conditions
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| Forms
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- Syrup
- Oral Suspension
- Tablet form
- Capsule form
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| Onset and duration
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- Oral administration onset: 15-30 minutes[1]
- Suppression of wheal & flare response to allergenic skin extract: 4 days.[2]
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| Serum level
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- Pruritus: 6-42 μg/L (14-102 nmol/L) (Suppresses pruritus in children)[3]
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| Fate
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Peak serum level
- Healthy adults -- 73 ± 11 μg/L occurs 2 ± 0.4 hr after a 0.7 mg/kg dose
- Primary biliary cirrhosis -- 117 ± 61 μg/L at 2.3 ± 0.7 hr after 44mg mean dose
Vd
- Children -- 19 ±9 L/kg
- Healthy adults -- 16 ± 3 L/kg
- Elderly -- 23 ± 6 L/kg
- Primary biliary cirrhosis -- 23 ±13 L/kg
Cl
- Children -- 1.9 L/hr/kg
- Healthy young/elderly adults -- 0.6 ± 0.2 L/hr/kg
- Primary biliary cirrhosis -- 0.5 ±0.4 L/hr/kg
t½
- Children -- 7hr (increases with age)
- Healthy adults -- 20 ± 4 hr
- Elderly -- 29 ± 10 hr
- Primary biliary cirrhosis -- 37 ±13 hr
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References
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- ↑ Usdin Yasuda S et al. Chlorpheniramine plasma concentration and histamine H1-receptor occupancy. Clin Pharmacol Ther 1995;58:210-20.
- ↑ Gendreau-Reid L et al. Comparison of the suppressive effect of astemizole, terfenadine, and hydroxyzine on
histamine-induced wheals and flares in humans. J Allergy Clin Immunol 1986;77:335-40.
- ↑ Simons FER et al. Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis. J Pediatr1984;104:123μ7.
