Hydroxyzine/reference table

From Self-sufficiency
Jump to: navigation, search
This page is a medical information page -- A quick-reference of prescription, dosage, and other data for medical professionals and others interested in ascertaining the applicability/effectiveness of their treatment.
General classification
  • Antihistamine -- Competitive antagonist of histamine, H1 histamine receptor and antiemetic, anxiolytic.
Prescriptive conditions
Forms
  • Syrup
  • Oral Suspension
  • Tablet form
  • Capsule form
Onset and duration
  • Oral administration onset: 15-30 minutes[1]
  • Suppression of wheal & flare response to allergenic skin extract: 4 days.[2]
Serum level
  • Pruritus: 6-42 μg/L (14-102 nmol/L) (Suppresses pruritus in children)[3]
Fate

Peak serum level

  • Healthy adults -- 73 ± 11 μg/L occurs 2 ± 0.4 hr after a 0.7 mg/kg dose
  • Primary biliary cirrhosis -- 117 ± 61 μg/L at 2.3 ± 0.7 hr after 44mg mean dose

Vd

  • Children -- 19 ±9 L/kg
  • Healthy adults -- 16 ± 3 L/kg
  • Elderly -- 23 ± 6 L/kg
  • Primary biliary cirrhosis -- 23 ±13 L/kg

Cl

  • Children -- 1.9 L/hr/kg
  • Healthy young/elderly adults -- 0.6 ± 0.2 L/hr/kg
  • Primary biliary cirrhosis -- 0.5 ±0.4 L/hr/kg

t½

  • Children -- 7hr (increases with age)
  • Healthy adults -- 20 ± 4 hr
  • Elderly -- 29 ± 10 hr
  • Primary biliary cirrhosis -- 37 ±13 hr

References

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />
  1. Usdin Yasuda S et al. Chlorpheniramine plasma concentration and histamine H1-receptor occupancy. Clin Pharmacol Ther 1995;58:210-20.
  2. Gendreau-Reid L et al. Comparison of the suppressive effect of astemizole, terfenadine, and hydroxyzine on histamine-induced wheals and flares in humans. J Allergy Clin Immunol 1986;77:335-40.
  3. Simons FER et al. Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis. J Pediatr1984;104:123μ7.