Kelliphite
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| Kelliphite | |
|---|---|
| File:Kelliphite structure.png | |
| 6,6'-[(1,1'-Biphenyl-2,2'-diyl)bis(oxy)]bis[4,8-di-tbutyl-1,2,10,11-tetramethyl]dibenzo[d,f][1,3,2]dioxaphosphepin | |
| Other names Kelliphite | |
| style="background: #F8EABA; text-align: center;" colspan="2" | Properties | |
| Molecular formula | C60H72O6P2 |
| Molar mass | 951.16 g mol−1 |
| Solubility in water | organic solvents |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
Kelliphite is an acronym for the organophosphorus compound 6,6'-[(1,1'-Biphenyl-2,2'-diyl)bis(oxy)]bis[4,8-di-tbutyl-1,2,10,11-tetramethyl]dibenzo[d,f][1,3,2]dioxaphosphepin. This chiral ligand is widely used in asymmetric synthesis.[1][2] In one example, this ligand is used to form a rhodium complex to catalyze asymmetric hydroformylation of prochiral olefins. It has been shown that high substrate concentrations as well as a wide variety of functional groups are tolerated. [3]
References
- ↑ Clark, Thomas P. (2005). "Highly Active, Regioselective, and Enantioselective Hydroformylation with Rh Catalysts Ligated by Bis-3,4-diazaphospholanes". J. Am. Chem. Soc. 127: 5040. doi:10.1021/ja050148o.
- ↑ Cobley, Christopher J. (2004). "Synthesis and Application of a New Bisphosphite Ligand Collection for Asymmetric Hydroformylation of Allyl Cyanide". J. Org. Chem. 69: 4031. doi:10.1021/jo040128p.
- ↑ Cobley, Christopher J.; Klosin, Jerzy; Qin, Cheng; Whiteker, Gregory T. (2004). "Parallel Ligand Screening on Olefin Mixtures in Asymmetric Hydroformylation Reactions". Org. Lett. 6: 3277. doi:10.1021/ol0487938.
