Lemont Kier
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Lemont Kier is an American chemist and leader in the field of Drug Design and Medicinal Chemistry.[1] He is the recipient of the American Association of Pharmaceutical Scientists 2008 Research Achievement Award in Drug Development and Discovery.[2] He obtained his PhD in Medicinal Chemistry at the University of Minnesota in 1958. He is currently a Professor of Medicinal Chemistry and Nurse Anesthesia at the Virginia Commonwealth University in Richmond.Professor Kier built one of the first models in which molecular orbital theory was applied successfully to drug design and development. In this model, he and his colleague developed what is now called the "Kier-Hall Index" to describe molecular connectivity.[3][4] His particular expertise in the question “How do chemical modifications affect particular physical properties of drugs?” has been used by Prof. Kier and others to develop the theory of the interaction of general anesthetic gases with the body [5], and the theory of taste (and in particular, sweetness [6]). He owns a Rolls-Royce which has the number plate stating "QSAR". He uses the key to his car to explain a perfect analogy of ligand receptor binding.
Professor Kier is the author or co-author of eight books: Molecular Orbital Theory In Drug Research; [7] Molecular Connectivity In Chemistry and Drug Research; [8]Molecular Connectivity in Structure Activity Analysis;[9] Molecular Structure Description: The Electrotopological State;[10] Medicinal Chemistry and Physics for Nurse Anesthetists; [11] Cellular Automata Modeling of Chemical Systems;[12] and Science and Complexity for Life Science Students.[13]
Notes
- ↑ See, for instance Richmond Times and Dispatch, Feb. 26, 2004 "Three Named Top Virginia Scientists"
- ↑ http://www.aapspharmaceutica.com/inside/awards_fellows/awardslist.asp
- ↑ "From chemical topology to three-dimensional geometry" by Alexandru T. Balaban, Springer Books, 1997, p. 7
- ↑ Molecular drug properties: measurement and prediction - Google Books Result by Raimund Mannhold, Wilel VVH (2007) pp. 88-90
- ↑ Molecular Connectivity and SAR of General Anesthetics. T. Dipaolo, L. B. Kier and L. H. Hall, Molec. Pharmacol., 13, 31 (1977)
- ↑ Sweetness, Wikipedia article
- ↑ Molecular Orbital Theory In Drug Research. L. B. Kier, Academic Press, New York (1971)
- ↑ Molecular Connectivity In Chemistry and Drug Research L. B. Kier and L. H. Hall, Academic Press, New York (1976)
- ↑ Molecular Connectivity in Structure Activity Analysis. L. B. Kier and L. H. Hall, John Wiley Publ, London (1986)
- ↑ Molecular Structure Description: The Electrotopological State L. B. Kier and L. H. Hall, Academic Press, San Diego, (1999)
- ↑ Medicinal Chemistry and Physics for Nurse Anesthetists L. B. Kier and C. Dowd Amer. Assoc. of Nurse Anesthetists, Chicago (2004)
- ↑ Cellular Automata Modeling of Chemical Systems. L. B. Kier, P. G. Seybold and C.-K. Cheng, Springer, Amsterdam (2005)
- ↑ Science and Complexity for Life Science Students. L. B. Kier, Kendall/Hunt, Dubuque, IO, (2007)
