Leu-enkephalin

From Self-sufficiency
Jump to: navigation, search
Leu-enkephalin
File:Leu-enkaphalin.png
style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers
CAS number 58822-25-6
PubChem 10415290
IUPHAR ligand 1613
SMILES Script error: No such module "collapsible list".
style="background: #F8EABA; text-align: center;" colspan="2" | Properties
Molecular formula C28H37N5O7
Molar mass 555.62268 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Leu-enkephalin is an endogenous opioid peptide neurotransmitter found naturally in the brains of many animals, including humans. It is one of the two forms of enkephalin; the other is met-enkephalin. The tyrosine residue at position 1 is thought to be analogous to the 3-hydroxyl group on morphine.

Leu-Enkephalin is a peptide whose sequence is: Tyr - Gly - Gly - Phe - Leu. It produces pharmacological effects at both the mu and delta opioid receptors, showing selectivity for the delta receptor.

It has a much higher selectivity for δ opioid receptors than μ receptors, and has little to no effect on κ opioid receptors.