Leu-enkephalin
From Self-sufficiency
Leu-enkephalin | |
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File:Leu-enkaphalin.png | |
(2R)-2-[[(2R)-2-[[2-[[2-[[(2R)-2-amino-3- (4-hydroxyphenyl)propanoyl]amino]acetyl] amino]acetyl]amino]-3-phenylpropanoyl] amino]-4-methylpentanoic acid | |
style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers | |
CAS number | 58822-25-6 |
PubChem | 10415290 |
IUPHAR ligand | 1613 |
SMILES | Script error: No such module "collapsible list". |
style="background: #F8EABA; text-align: center;" colspan="2" | Properties | |
Molecular formula | C28H37N5O7 |
Molar mass | 555.62268 g/mol |
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
Infobox references |
Leu-enkephalin is an endogenous opioid peptide neurotransmitter found naturally in the brains of many animals, including humans. It is one of the two forms of enkephalin; the other is met-enkephalin. The tyrosine residue at position 1 is thought to be analogous to the 3-hydroxyl group on morphine.
Leu-Enkephalin is a peptide whose sequence is: Tyr - Gly - Gly - Phe - Leu. It produces pharmacological effects at both the mu and delta opioid receptors, showing selectivity for the delta receptor.
It has a much higher selectivity for δ opioid receptors than μ receptors, and has little to no effect on κ opioid receptors.
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