Losigamone

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Losigamone
File:Losigamone skeletal.svg
Systematic (IUPAC) name
(2R)-2-[(S)-(2-chlorophenyl)-hydroxymethyl]-3-methoxy-2H-furan-5-one
Legal status
Legal status
  • investigational
Identifiers
ATC code none
PubChem CID 6918049
Chemical data
Formula C12H11ClO4
Molar mass 254.666 g/mol[[Script error: No such module "String".]]
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Losigamone is an investigational drug for the treatment of epilepsy. It has been studied as an add-on treatment for partial seizures.[1] Phase III clinical trials were conducted around the year 2000.[2]

Mechanism of action

The mechanism of action is not known. Data regarding the interaction of losigamone with GABA receptors are inconsistent: it increases GABA-induced chloride influx in spinal cord neuron cultures, but has no significant influence on GABAergic inhibitory postsynaptic potentials in hippocampal slices.[2] Interaction with potassium[2] and sodium channels[3] has been proposed.

References

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  1. ↑ Baulac, M; Klement, S; Losigamone Study, Group (2003). "Efficacy and Safety of Losigamone in Partial Seizures: A Randomized Double-Blind Study". Epilepsy Res. 55 (3): 177–189. doi:10.1016/S0920-1211(03)00108-6. PMID 12972172. 
  2. ↑ 2.0 2.1 2.2 Willmore, LJ (December 2001). "Losigamone. Dr Willmar Schwabe". Curr Opin Investig Drugs. 2 (12): 1763–6. PMID 11892943. 
  3. ↑ Draguhn, A; Jungclaus, M; Sokolowa, S; Heinemann, U (May 1997). "Losigamone decreases spontaneous synaptic activity in cultured hippocampal neurons". European Journal of Pharmacology. 325 (2–3): 245–251. doi:10.1016/S0014-2999(97)00121-0. PMID 9163572. 
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