Macroketone

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Macroketone
File:Macroketone.png
style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers
PubChem 45100507
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style="background: #F8EABA; text-align: center;" colspan="2" | Properties
Molecular formula C17H28O3
Molar mass 280.40242
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Macroketone is a synthetic substance based on the fourteen-membered lactone ring found in the bacterial antibiotic migrastatin, which stops cancer cell metastasis in some animal models.[1][2] Macroketone targets an actin cytoskeletal protein known as fascin that is critical to cell adhesion.[2]

References

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External links

  • Anquetin G, Horgan G, Rawe S, Murray D, Madden A, MacMathuna P, Doran P, Murphy PV (2008). "Synthesis of Novel Macrolactam and Macroketone Analogues of Migrastatin from D-Glucal and Comparison with Macrolactone and Acyclic Analogues: A Dorrigocin A Congener Is a Potent Inhibitor of Gastric Cancer Cell Migration". European Journal of Organic Chemistry. 2008 (11): 1953–1958. doi:10.1002/ejoc.200701192. 
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