Mapatumumab

Mapatumumab

Monoclonal antibody
Type	Whole antibody
Source	Template:Infobox drug/mab source
Target	TRAIL-receptor (death receptor 4)
Identifiers
CAS Number	658052-09-6
ATC code	none
Chemical data
Formula	C6748H10408N1800O2092S52
Molar mass	151.89 kDa[[]]

Mapatumumab (HGS-ETR1) is a human monoclonal antibody designed for the treatment of cancer.

This drug was discovered by Cambridge Antibody Technology (CAT) and Human Genome Sciences, Inc. (HGS) as a result of the collaboration between the two companies in 1999 in exploitation CAT's phage display technology. Early work by CAT and HGS indicated that mapatumumab induced cell death in multiple tumour types both in vitro and in vivo.

Clinical trials

A phase 1 clinical trial in 2004 demonstrated the safety and tolerability of mapatumumab in cancer patients with advanced solid tumors or non-Hodgkin’s lymphoma, and supported further evaluation in phase 2 clinical trials, both as a single agent and in combination with chemotherapy.

2005: In a phase 2 clinical trial mapatumumab was well tolerated and could be administered safely in patients with advanced non-small cell lung cancer (NSCLC) and advanced colorectal cancer. Stable disease was observed in a number of NSCLC patients.

In two phase 1b clinical trials mapatumumab in combination with chemotherapy was well tolerated by patients with advanced solid tumors. Partial response was observed in a number of patients in each of the studies.

The results of a phase 2 clinical trial demonstrated that mapatumumab was well tolerated and capable of producing clinical responses when administered as monotherapy in patients with advanced non-Hodgkin’s lymphoma, according to HGS.

Multiple myeloma

In 2008 HGS reported initial results of a randomised phase 2 trial of mapatumumab in combination with bortezomib in advanced multiple myeloma. However, in 2010, mapatumumab failed in a midstage study. There was no difference in disease response or progression-free survival rates between patients receiving the drug for multiple myeloma and the control group.

Non-small cell lung cancer

"In August 2008, ... initial dosing of patients in a randomized Phase 2 trial of HGS-ETR1 (10 mg/kg or 30 mg/kg) in combination with paclitaxel and carboplatin as first-line therapy in patients with advanced non-small cell lung cancer (NSCLC); initial data from the study are anticipated in 2009."

Liver cancer

"In July 2008, HGS initiated dosing in ... a randomized Phase 2 trial of HGS-ETR1 in combination with Nexavar (sorafenib) in patients with advanced hepatocellular cancer, which accounts for 80-90% of all liver cancers."