Norbolethone

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Norbolethone
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Systematic (IUPAC) name
13-ethyl-17-hydroxy-18,19-dinor-17-pregn-4-en-3-one
Identifiers
CAS Number 1235-15-0
ATC code none
PubChem CID 66255
Chemical data
Formula C21H32O2
Molar mass 316.47758 g/mol[[Script error: No such module "String".]]
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Norbolethone (Genabol) is an anabolic steroid. It was first developed in 1966 by Wyeth Laboratories, and tested for use as an agent to encourage weight gain and for the treatment of short stature, but was never marketed commercially because of fears that it might be toxic.[1] It subsequently showed up in urine tests on athletes in competition in the early 2000s.[2]

Norbolethone was found to have been brought to the market by the chemist Patrick Arnold, of the Bay Area Laboratory Co-operative (BALCO), an American nutritional supplement company. It is reputed to have been the active ingredient in the original formulation of the "undetectable" steroid formulation known as "The Clear" before being replaced by the more potent drug tetrahydrogestrinone.[3][4]

In 2002, Don Catlin, MD, the founder and then-director of the UCLA Olympic Analytical Lab, identified for the first time in an athlete’s urine sample norbolethone, the first reported "designer" anabolic steroid. In the same year, U.S. bicycle racer Tammy Thomas was caught using it and was banned from her sport.[1] The following year, Catlin identified and developed a test for tetrahydrogestrinone or THG, the second reported designer anabolic sample—a key development in the BALCO Affair.[5]


References

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Anabolic steroids (A14) (tradename in brackets)
Androstane (carbon 19 present)
Adrenosterone • Androisoxazole • Bolasterone (Myagen) • Bolazine • Boldione • Boldenone undecylenate (Equipoise) • 4-Chlordehydromethyltestosterone (Turinabol) • 4-Hydroxytestosterone • Calusterone • Clostebol • Danazol • Desoxymethyltestosterone (Madol) • DHT • Drostanolone (Masteron) • Enestebol • Epitiostanol • Fluoxymesterone (Halotestin) • Formebolone • Furazabol (Miotolan) • Hydroxystenozole • Mebolazine • Mesabolone • Mestanolone • Mesterolone (Proviron) • Methandriol • Methandrostenolone (Dianabol) • Methenolone • Methenolone enanthate (Primobolan) • Methasterone (Superdrol) • Methyltestosterone • Oxandrolone (Anavar) • Oxymetholone (Anadrol) • Oxymesterone • Prostanozol • Quinbolone (Anabolicum Vister) • Roxibolone • Silandrone • Stanozolol (Strombafort, Winstrol) • Stenbolone • Testosterone`s (Sustamed, Sustanon) • 1-Testosterone • Thiomesterone • Trestolone
Estrene (carbon 19 absent)
Prohormones


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  1. ↑ 1.0 1.1 Lee, Henry K. (2006-08-04). The San Francisco Chronicle http://www.sfgate.com/cgi-bin/article.cgi?file=/c/a/2006/08/04/MNG3LKBCR712.DTL&type=printable.  Missing or empty |title= (help)
  2. ↑ Catlin DH, Ahrens BD, Kucherova Y. Detection of norbolethone, an anabolic steroid never marketed, in athletes' urine. Rapid Communications in Mass Spectrometry. 2002;16(13):1273-5.
  3. ↑ "Chemist Who Created "The Clear" Sentenced" (Press release). United States Attorney for the Northern District of California. 2006-08-04. http://www.usdoj.gov/usao/can/press/2006/2006_08_04_arnold_sentencing%20press.htm. Retrieved 2007-10-08. 
  4. ↑ Knight J. Drugs bust reveals athletes' secret steroid. Nature. 2003 Oct 23;425(6960):752.
  5. ↑ Catlin has made a career out of busting juicers, USA Today, 2007-02-28.
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