PK/PD models
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PK/PD (Pharmacokinetic/Pharmacodynamic) modeling is a technique that combines the two classical pharmacologic disciplines of pharmacokinetics and pharmacodynamics. It integrates a pharmacokinetic and a pharmacodynamic model component into one set of mathematical expressions that allows the description of the time course of effect intensity in response to administration of a drug dose.
There are a variety of PK/PD modeling approaches, but there are only five major classes:
Direct link PK/PD models
Indirect link PK/PD models
Indirect response PK/PD models
Cell Lifespan models
Complex response models
Referenced from:
Pharmaceutical Biotechnology: Fundamentals and Applications. Crommelin, Daan; Meibohm, Bernd; Sindelar, Robert. Third Edition. Informa Healtcare USA. 2008.
